下一代疗法

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Creating the next generation of therapeutics

澳门葡京赌博游戏正在不断推动科学的发展，以提供改变生活的药物，这些药物将对澳门葡京赌博游戏致力于治疗的疾病产生最大和最快的影响, 防止, 修改和将来, 甚至治愈. 只有加强澳门葡京赌博游戏对疾病生物学的理解，发现针对疾病驱动因素的新方法，澳门葡京赌博游戏才能在肿瘤学的主要治疗领域创造下一代治疗方法, 心血管, 肾脏与代谢, 呼吸和免疫学.

We are already leveraging the rapid advancements in science and technology to create new therapeutics, 如细胞治疗, 抗体疗法, and nucleotide-based therapeutics, for disease mechanisms which were previously considered difficult, 如果不是不可能的话, 为目标.¹ 另外, we are working on integrating knowledge of drug candidates and their interactions with their target, 疾病的病理生理学和给药系统，以便设计先进的给药技术.²Each new insight and every new piece of information brings us closer to creating better, more advanced and more effective treatments for patients.

与世界各地的合作者合作，正在帮助澳门葡京赌博游戏的科学家开拓药物发现的新方法. 事实上, 30% of our early pipeline now consists of new drug modalities including oligonucleotides, mRNA和antialin^® 蛋白质.

The technological toolbox fuelling our
新一代的管道

选择与疾病驱动因素有密切联系的正确靶标仍然是澳门葡京赌博游戏在药物发现过程中做出的最重要的决定. 一旦选择了这个目标, 澳门葡京赌博游戏现在有了一个由传统分子和创新分子组成的工具箱，澳门葡京赌博游戏可以利用它们来瞄准新的生物学. You can explore our toolbox of modalities below.

小分子

澳门葡京赌博游戏在发现和开发口服小分子药物方面有着悠久的历史，利用创新的方法来设计和给药. 小分子可以被设计成通过各种作用模式参与生物目标，并在细胞内和细胞外发挥作用. 它们的分布可以进一步调整，以允许有或没有穿透大脑的全身暴露. 点击下面的瓷砖阅读更多关于澳门葡京赌博游戏对传统小分子的研究，这些小分子一直是澳门葡京赌博游戏业务的基石, 以开创性的, new small-molecule approaches 如 PROTACs and zirconium cyclosilicates.

小分子 continue to be an important therapeutic and we are bringing innovative approaches, 比如人工智能, machine learning and new chemistries, to small molecule discovery and development. Read more >>

PROTACs, or PROteolysis TArgeting Chimeras, can degrade unwanted or damaging 蛋白质 in cells with high specificity. 通过其独特的作用模式，它们有可能靶向以前“不可药物”的蛋白质. Read more >>

这个小, 无机化合物类作为一种高选择性离子结合剂在治疗心血管疾病中常见的高血钾水平中发现了新的应用. Read more >>

抗体疗法

抗体可以非常准确地靶向蛋白质，并且可以通过工程设计来提高特异性, 效力和亲和力. 澳门葡京赌博游戏正在扩大澳门葡京赌博游戏的抗体工程平台的范围，并设计新的和改进的治疗方法，如双特异性抗体和片段抗体，目的是获得难以达到的治疗靶点. 点击下面的图片，了解更多关于澳门葡京赌博游戏创造下一代抗体疗法的研究成果.

Well-known for their specificity and selectivity, 澳门葡京赌博游戏利用澳门葡京赌博游戏广泛的抗体发现和蛋白质工程平台来创建用于治疗应用的单克隆抗体. Read more >>

Combining the power of small molecule agents with the precision of antibodies, these therapeutics have the potential to reduce the most damaging side effects of chemotherapy. Read more >>

Unique in their ability to bind two targets at the same time, 双特异性抗体提供了许多可能的治疗组合，并具有提高靶标特异性的潜力. Read more >>

Broken down from larger antibody molecules, their size can help access difficult-to-reach therapeutic targets, making them a small but mighty tool in fighting disease. Read more >>

t细胞接合物是一种新型的双特异性抗体，它能将免疫系统的t细胞定向到癌细胞上. Read more >>

肽或蛋白质疗法

Through our long-standing expertise in protein engineering, we are advancing both conventional and novel classes of protein and peptide therapies. Because 蛋白质 are large molecules, 它们通常不具有细胞渗透性，传统上仅限于细胞外靶点和注射给药途径. Peptides constitute a smaller format of protein therapeutics. They are typically developed as small, specific and highly selective ligands for extracellular targets.

通过各种合作, 澳门葡京赌博游戏不仅在探索开发传统的蛋白质疗法和多肽，而且还在探索潜在的创新疗法，如antialin®蛋白质和双环肽. Click the tiles below to read more about these novel drug modalities.

Underpinned by our protein engineering expertise, 澳门葡京赌博游戏正在探索开发针对新的和具有挑战性的疾病靶点的各种治疗性蛋白质. Read more >>

Mimicking the selectivity of antibodies, these highly adaptable and versatile next generation biopharmaceuticals combine specificity, 效力, and safety with significantly reduced size affording greater tissue penetration. Read more >>

这些独特的工程蛋白提供了一种潜在的抗体替代品，它们的尺寸更小，可以在保持特异性的同时更大地渗透到组织中. They have the potential to be delivered through non-injectable routes 如 inhalation. Read more >>

Nucleotide-based疗法 & 基因治疗

Recent advances in genomics has led to a myriad of potential new drug targets and with it, the opportunity for nucleotide-based therapeutics to have a real impact on disease. 澳门葡京赌博游戏正在探索一些基于核苷酸的方式，从寡核苷酸和基于rna的治疗到使用CRISPR/Cas9作为潜在的治疗工具. Click the tiles below to read more about these novel drug modalities.

基于核苷酸的治疗方法提供了巨大的潜力，可以通过精确的医学方法实现持久的治疗

使用CRISPR/Cas9进行精确的基因组编辑正在成为许多遗传疾病的有前途的治疗途径. Read more >>

细胞疗法

澳门葡京赌博游戏正在迅速推进澳门葡京赌博游戏在干细胞和细胞修复和再生领域的研究工作. 澳门葡京赌博游戏的目标是为患者带来基于细胞的疗法，这种疗法有可能阻止甚至逆转疾病的进程. Read more about how we are harnessing the power of living cells as a new therapeutic modality. >>

IVEBs

Bringing together our knowledge of biologics discovery and development and therapeutic gene editing, 体内表达生物制剂(IVEBs)具有刺激组织在患者自身体内产生生物制剂的潜力. This could address crucial unmet medical needs, 包括传染病, and offer significant benefits to patients and healthcare systems. Read more about this potential one-shot approach to delivering biologic medicines. >>

Meet some of our pioneers of next generation therapeutics

Behind every advancement we make, there is a team of dedicated scientists. Find out more about some of our researchers working at the cutting-edge of drug discovery: